Insulin-like growth factor-I stimulates proliferation of mouse uterine epithelial cells in primary culture.

@article{Shiraga1997InsulinlikeGF,
  title={Insulin-like growth factor-I stimulates proliferation of mouse uterine epithelial cells in primary culture.},
  author={Minoru Shiraga and Sumio Takahashi and Takashi Miyake and Sakae Takeuchi and Hiroshi Fukamachi},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1997},
  volume={215 4},
  pages={412-7}
}
Estrogens stimulate proliferation and differentiation of uterine epithelial cells in vivo. Mitogenic action of estrogens may be mediated by growth factors such as insulin-like growth factor-I (IGF-I). This study was designed to determine whether IGF-I and insulin affect proliferation of uterine epithelial cells obtained from 3- to 4-week-old immature female mice in a serum-free culture system. The epithelial cell number on Day 5 in culture was significantly increased by adding IGF-I (10 and 100… CONTINUE READING

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