Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes.

Abstract

Adult rat cardiomyocytes in long-term culture express type 1 insulin-like growth factor (IGF) receptors. In contrast to insulin receptors, type 1 IGF receptors are up-regulated during culturing. IGF-I added to the cells at plating increased granular density and pseudopodia number per cell after 7 days. After 16 days, IGF-I-treated cells showed, as compared… (More)

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@article{Donath1994InsulinlikeGF, title={Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes.}, author={Max Donath and Jurgen Zapf and Monika E. Eppenberger-Eberhardt and E. Rudolf Froesch and H. M. 308 Erbel Eppenberger}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1994}, volume={91 5}, pages={1686-90} }