Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells.

@article{Badesch1989InsulinlikeGF,
  title={Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells.},
  author={David B. Badesch and Phillip D. K. Lee and William C. Parks and Kurt R Stenmark},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={160 1},
  pages={382-7}
}
Insulin-like growth factor I stimulates mitogenesis in smooth muscle cells, and upregulates elastin synthesis in embryonic aortic tissue. Increased smooth muscle elastin synthesis may play an important role in vascular remodeling in chronic pulmonary hypertension. Therefore, we studied the effect of IGF-I on elastin and total protein synthesis by pulmonary arterial smooth muscle cells in vitro. Tropoelastin synthesis was measured by enzyme immunoassay, and total protein synthesis was measured… CONTINUE READING

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