Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophy.

@article{Shavlakadze2005InsulinlikeGF,
  title={Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophy.},
  author={Thea Shavlakadze and Jason D. White and Marilyn Davies and Joseph Foon Yoong Hoh and Miranda D Grounds},
  journal={Neuromuscular disorders : NMD},
  year={2005},
  volume={15 2},
  pages={139-46}
}
Loss of the nerve supply to skeletal muscle results in a relentless loss of muscle mass (atrophy) over time. The ability of insulin-like growth factor-1 to reduce atrophy resulting from denervation was examined after transection of the sciatic nerve in transgenic MLC/mIGF-1 mice that over-express mIGF-1 specifically in differentiated myofibres. The cross sectional area (CSA) of all types of myofibres and specifically type IIB myofibres was measured in tibialis anterior muscles from transgenic… CONTINUE READING
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Electron microscopic study of long-term denervated rat skeletal muscle

  • Lu D-X, Huang S-K, BM Carlson
  • Anat Rec
  • 1997
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