Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.

@article{Wu2010InsulinlikeGF,
  title={Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.},
  author={Yingjie Wu and Pnina Brodt and Hui Sun and Wilson Giraldo Mej{\'i}a and Ruslan Novosyadlyy and Nomel{\'i} P. N{\'u}{\~n}ez and Xiaoli Chen and Amado Gonz{\'a}lez Mendoza and Sung-Hyeok Hong and C. K. Raghul Khanna and Shoshana Yakar},
  journal={Cancer research},
  year={2010},
  volume={70 1},
  pages={
          57-67
        }
}
Among the mechanisms implicated in the tumor-promoting effects of obesity, signaling by insulin-like growth factor-I (IGF-I) and insulin has received considerable attention. However, the emerging realization that obesity is associated with chronic inflammation has prompted other consideration of how the IGF-I axis may participate in cancer progression. In the present study, we used two mouse models of chronic (LID) and inducible (iLID) igf-1 gene deficiency in the liver to investigate the role… CONTINUE READING

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Recombinant human Cancer Research h. r 13, 2017

  • JH Antin, HJ Weinstein, EC Guinan
  • Blood
  • 2010
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