Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.

@article{Kim2008InsulinlikeGF,
  title={Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.},
  author={Jaetaek Kim and Adam R. Wende and Sandra Sena and Heather A. Theobald and Jamie E Soto and Crystal L Sloan and Benjamin E Wayment and Sheldon E. Litwin and Martin Holzenberger and Derek Leroith and E. Dale Abel},
  journal={Molecular endocrinology},
  year={2008},
  volume={22 11},
  pages={
          2531-43
        }
}
The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with cardiomyocyte-specific knockout of IGF-IR (CIGF1RKO) and compared them with cardiomyocyte-specific insulin receptor knockout (CIRKO) mice in response to 5 wk exercise swim training. Cardiac development was normal in CIGF1RKO mice, but the hypertrophic response to exercise was prevented. In… CONTINUE READING

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