Insulin-like growth factor-I receptor signaling blockade combined with radiation.

@article{Allen2007InsulinlikeGF,
  title={Insulin-like growth factor-I receptor signaling blockade combined with radiation.},
  author={Gregory W Allen and Corey F. Saba and Eric A. Armstrong and S M Huang and Sergio Benavente and Dale L. Ludwig and Daniel J. Hicklin and Paul M. Harari},
  journal={Cancer research},
  year={2007},
  volume={67 3},
  pages={1155-62}
}
Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy over conventional treatments alone. In this study, a fully human anti-IGF-IR monoclonal antibody A12 (ImClone Systems, Inc., New York, NY) is examined as an adjunct to radiation… CONTINUE READING