Insulin-like growth factor I rapidly enhances acid efflux from osteoblastic cells.

@article{Santhanagopal1999InsulinlikeGF,
  title={Insulin-like growth factor I rapidly enhances acid efflux from osteoblastic cells.},
  author={Anu Santhanagopal and S. Jeffrey Dixon},
  journal={The American journal of physiology},
  year={1999},
  volume={277 3},
  pages={
          E423-32
        }
}
Insulin-like growth factor I (IGF-I) is thought to stimulate bone resorption indirectly through a primary effect on osteoblasts, which in turn activate osteoclasts by as-yet-unidentified mechanisms. Small decreases in extracellular pH (pHo) dramatically increase the resorptive activity of osteoclasts. Our purpose was to characterize the effect of IGF-I on acid production by osteoblastic cells. When confluent, UMR-106 osteoblast-like cells and rat calvarial cells acidified the compartment… CONTINUE READING

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