Insulin-like growth factor-I promotes proliferation and migration of cavernous smooth muscle cells.

@article{Liu2001InsulinlikeGF,
  title={Insulin-like growth factor-I promotes proliferation and migration of cavernous smooth muscle cells.},
  author={Xiaorong Liu and Ching-shwun Lin and E. Martin Spencer and Tom F. Lue},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={280 5},
  pages={1307-15}
}
To better understand the physiology of cavernous smooth muscle cells (CSMC), particularly their regulation by IGF-I, we isolated CSMC from rats of various ages and grew them as cell cultures. CSMC from very young (1 week of age) and very old (28 months of age) rats secreted the least amounts of IGF-I, and those from 16-week-old rats the most. IGF-I… CONTINUE READING