Insulin-like growth factor I in the kidney.

  title={Insulin-like growth factor I in the kidney.},
  author={Raimund R Hirschberg},
  journal={Mineral and electrolyte metabolism},
  volume={22 1-3},
Insulin-like growth factor I (IGF-I) is synthesized in renal glomeruli and distal tubules. The rather high serum IGF-I levels (20-40 nM) result mainly from synthesis in the liver. In the circulation > or = 99% of IGF-I is bound in binding protein complexes. IGF-I can act in the kidney by autocrine and paracrine as well as endocrine modes. IGF-I raises GFR through reducing arteriolar resistance and increasing LpA. The peptide also increases the tubule transport of phosphate both in vitro and in… CONTINUE READING
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