Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders.

@article{Singh1999InsulinlikeGF,
  title={Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders.},
  author={Maria Antoinette Fiatarone Singh and Wenjing Ding and Thomas J Manfredi and Guido S Solares and Evelyn F O'Neill and Karen M Clements and Nancy D Ryan and Joseph J. Kehayias and Roger A Fielding and William J Evans},
  journal={The American journal of physiology},
  year={1999},
  volume={277 1 Pt 1},
  pages={E135-43}
}
To assess muscle remodeling and functional adaptation to exercise and diet interventions, 26 men and women aged 72-98 yr underwent a vastus lateralis biopsy before and after placebo control condition, and progressive resistance training, multinutrient supplementation, or both. Type II atrophy, Z band, and myofibril damage were present at baseline. Combined weight lifting and nutritional supplementation increased strength by 257 ± 62% ( P = 0.0001) and type II fiber area by 10.1 ± 9.0% ( P = 0… CONTINUE READING
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