Insulin-like growth factor I in pregnancy and maternal risk of breast cancer.

  title={Insulin-like growth factor I in pregnancy and maternal risk of breast cancer.},
  author={Annekatrin Lukanova and Paolo G. Toniolo and Anne Zeleniuch-Jacquotte and Kjell Grankvist and Marianne Wulff and Alan A. Arslan and Yelena Afanasyeva and Robert Johansson and Per Lenner and G{\"o}ran Hallmans and G{\"o}ran Wadell and Eva A Lundin},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={15 12},
BACKGROUND The role of insulin-like growth factor (IGF)-I in breast cancer remains controversial, despite numerous reports on the association of the hormone with breast cancer or high-risk mammographic densities. We hypothesized that exposure to elevated IGF-I during early pregnancy, a period characterized by intense cell proliferation in the breasts and in the presence of high concentrations of sex steroids, will be associated with increased maternal risk to develop a breast malignancy… CONTINUE READING