Insulin-like growth factor I improves renal function in patients with end-stage chronic renal failure.

@article{Vijayan1999InsulinlikeGF,
  title={Insulin-like growth factor I improves renal function in patients with end-stage chronic renal failure.},
  author={Anitha Vijayan and Samuel C Franklin and Terry Behrend and Marc R. Hammerman and Steven B. Miller},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1999},
  volume={276 4},
  pages={R929-R934}
}
There is no pharmacological treatment to increase the glomerular filtration rate in end-stage renal disease (ESRD). The administration of 100 μg/kg of insulin-like growth factor (IGF) I twice a day to patients with ESRD increases inulin clearance. However, its effect is short-lived and IGF-I has major side effects when given this way. To assess whether the use of a lower intermittent dose of IGF-I would effect sustained improved function with tolerable side effects we performed 1) a prospective… CONTINUE READING

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