Insulin-like growth factor-I improves recovery of cardiac performance during reperfusion in isolated rat heart by a wortmannin-sensitive mechanism.

@article{Otani2000InsulinlikeGF,
  title={Insulin-like growth factor-I improves recovery of cardiac performance during reperfusion in isolated rat heart by a wortmannin-sensitive mechanism.},
  author={Hajime Otani and Tsubasa Yamamura and Yoshihiro Nakao and Reiji Hattori and Hideaki Kawaguchi and Motohiko Osako and Hiroji Imamura},
  journal={Journal of cardiovascular pharmacology},
  year={2000},
  volume={35 2},
  pages={275-81}
}
Insulin-like growth factor-I (IGF-I) has been shown to produce a short-term positive inotropic effect (PIE) in the myocardium under nonischemic conditions. IGF-I also conferred cytoprotection against ischemia and reperfusion injury in various organs. IGF-I may, therefore, facilitate the recovery of postischemic cardiac function. Isolated and crystalloid-perfused rat heart was subjected to 25 min of normothermic ischemia followed by 30 min of reperfusion. IGF-I produced PIE in a dose-dependent… CONTINUE READING
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