Insulin-like growth factor I enhances the formation of type I collagen in hydrocortisone-treated human osteoblasts.

@article{Jonsson1993InsulinlikeGF,
  title={Insulin-like growth factor I enhances the formation of type I collagen in hydrocortisone-treated human osteoblasts.},
  author={Kenneth B. Jonsson and Sverker Ljunghall and Olle Karlstr{\"o}m and Andreas Johansson and Hans Mallmin and Osten Ljunggren},
  journal={Bioscience reports},
  year={1993},
  volume={13 5},
  pages={297-302}
}
We have studied the effect of insulin-like growth factor I (IGF-I) on the formation of osteocalcin and type I collagen in isolated human osteoblasts. IGF-I at and above 0.1 nM stimulated the formation of type I collagen as measured by the type I procollagen carboxyterminal peptide (PICP), in human osteoblasts, incubated for 72 hrs in serum free conditions. The secretion of osteocalcin was not affected by IGF-I while 1,25(OH)2vitamin D3 significantly enhanced the formation of osteocalcin. When… CONTINUE READING

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