Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells.

@article{Cara1990InsulinlikeGF,
  title={Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells.},
  author={Jos{\'e} F Cara and Jie Fan and Jo Azzarello and Robert L. Rosenfield},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={86 2},
  pages={560-5}
}
We tested the hypothesis that insulin-like growth factor-I (IGF-I) stimulates ovarian androgen production by increasing theca-interstitial cell luteinizing hormone (LH) binding affinity and/or binding capacity. We then investigated the role of transcriptional and translational events in mediating these actions of IGF-I. LH bound to saturable, high affinity binding sites on rat ovarian theca-interstitial cells. Preincubation with LH produced a decrease in LH binding capacity with no effect on LH… CONTINUE READING

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