Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells.

Abstract

We tested the hypothesis that insulin-like growth factor-I (IGF-I) stimulates ovarian androgen production by increasing theca-interstitial cell luteinizing hormone (LH) binding affinity and/or binding capacity. We then investigated the role of transcriptional and translational events in mediating these actions of IGF-I. LH bound to saturable, high affinity… (More)

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@article{Cara1990InsulinlikeGF, title={Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells.}, author={Jos{\'e} F Cara and Juan Fan and Joseph Azzarello and Robert L. Rosenfield}, journal={The Journal of clinical investigation}, year={1990}, volume={86 2}, pages={560-5} }