Insulin-like growth factor-I effects on gonadotropin-releasing hormone biosynthesis in GT1-7 cells.

@article{Longo1998InsulinlikeGF,
  title={Insulin-like growth factor-I effects on gonadotropin-releasing hormone biosynthesis in GT1-7 cells.},
  author={Karla M. Longo and Ya-ping Sun and Andrea C Gore},
  journal={Endocrinology},
  year={1998},
  volume={139 3},
  pages={
          1125-32
        }
}
  • Karla M. Longo, Ya-ping Sun, Andrea C Gore
  • Published in Endocrinology 1998
  • Medicine, Biology
  • The immortalized GT1-7 cell line synthesizes and secretes GnRH, the key hormone of reproduction. However, GT1-7 cells lack the normal inputs from neurotransmitters, growth factors, and steroids, which are involved in the maturation and maintenance of GnRH neurons in the brain. We examined the effects of the neurotrophic factor insulin-like growth factor-I (IGF-I) on GnRH gene expression and the mechanism for these changes. Initially, effects of IGF-I on GnRH gene expression were determined by… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 22 CITATIONS

    The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development.

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish.

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    Divergent roles of growth factors in the GnRH regulation of puberty in mice.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 44 REFERENCES

    Regulation of GnRH gene expression in vivo and in vitro

    • AC Gore, JL Roberts
    • Front Neuroendocrinol
    • 1997
    VIEW 2 EXCERPTS

    Gonadotropin-releasing hormone and NMDA receptor gene expression and colocalization change during puberty in female rats.

    VIEW 1 EXCERPT