Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.

@article{Bornfeldt1994InsulinlikeGF,
  title={Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.},
  author={Karin E Bornfeldt and Elaine W. Raines and Tohru Nakano and Lee M Graves and Edwin G. Krebs and Russell R. Ross},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 3},
  pages={1266-74}
}
Directed migration or chemotaxis of arterial smooth muscle cells (SMC) contributes to intimal SMC accumulation, a key event in the development of atherosclerotic lesions and in restenosis after angioplasty. The present study compares and contrasts insulin-like growth factor I (IGF-I) and platelet-derived growth factor (PDGF-BB) as chemoattractants and mitogens for human arterial SMC. Compared with PDGF-BB, IGF-I is a weaker SMC mitogen. Thus, PDGF-BB, but not IGF-I, evokes a strong and rapid… CONTINUE READING
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