Insulin-like growth factor-I and neurogenesis in the adult mammalian brain.

  title={Insulin-like growth factor-I and neurogenesis in the adult mammalian brain.},
  author={Michelle F. Anderson and Maria {\AA}berg and Michael Nilsson and Peter S. Eriksson},
  journal={Brain research. Developmental brain research},
  volume={134 1-2},
In most brain regions of highly developed mammals, the majority of neurogenesis is terminated soon after birth. However, new neurons are continually generated throughout life in the subventricular zone and the dentate gyrus of the hippocampus. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone that has demonstrated effects on these progenitor cells. IGF-I induces proliferation of isolated progenitors in culture, as well as affecting various aspects of neuronal induction and… CONTINUE READING
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