Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains.

@article{Jafferali2000InsulinlikeGF,
  title={Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains.},
  author={S Jafferali and Yvan Dumont and Florence Sotty and Yves O Robitaille and R{\'e}mi Quirion and Satyabrata Kar},
  journal={Synapse},
  year={2000},
  volume={38 4},
  pages={450-9}
}
Assimilated evidence indicates that the neurotoxic potential of amyloid beta (Abeta) peptide and an alteration in the level of growth factor(s) may possibly be involved in the loss of neurons observed in the brain of patients suffering from Alzheimer disease (AD), the prevalent cause of dementia in the elderly. In the present study, using receptor binding assays and immunocytochemistry, we evaluated the pharmacological profile of insulin-like growth factor-I (IGF-I) receptors and the… CONTINUE READING
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