Insulin-like growth factor I and its binding proteins in the experimental nephrotic syndrome.

@article{Hirschberg1995InsulinlikeGF,
  title={Insulin-like growth factor I and its binding proteins in the experimental nephrotic syndrome.},
  author={Raimund R Hirschberg and George Alan Kaysen},
  journal={Endocrinology},
  year={1995},
  volume={136 4},
  pages={1565-71}
}
Insulin-like growth factor I (IGF-I) is present in serum in association with specific IGF-binding proteins (IGFBPs) primarily in a large (approximately 150K) ternary or a smaller (approximately 50K) binary protein complex or in the free form (< or = 1%). We hypothesized that glomerular proteinuria results in urinary excretion of IGF-I/IGF-binding protein complexes and that the nephrotic syndrome induces abnormal serum distribution and liver synthesis of IGF-binding proteins. In nephrotic rats… CONTINUE READING