Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps.

Abstract

BACKGROUND & AIMS Insulin and insulin-like growth factor-I (IGF-I) affect proliferation, differentiation, and apoptosis and are potential risk factors for colorectal cancer (CRC). Visceral obesity, possibly via hyperinsulinemia, has also been linked to CRC risk. We evaluated the relationship of insulin, IGF-I, insulin-like growth factor binding protein… (More)

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