Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells.

@article{Simmons1995InsulinlikeGF,
  title={Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells.},
  author={J. G. Simmons and Eileen C Hoyt and John K. Westwick and David Brenner and Jolanta B Pucilowska and Pauline Kay Lund},
  journal={Molecular endocrinology},
  year={1995},
  volume={9 9},
  pages={1157-65}
}
Epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) exert trophic effects on bowel mucosa. Each growth factor uses a distinct tyrosine kinase receptor but the receptors share some common signal transduction pathways. In other systems, regulation of cell growth involves interactions among multiple growth factors. We used IEC-6 cells, an epithelial cell line established from rat small intestine, to test whether EGF and IGF-I interact to regulate intestinal epithelial cell… CONTINUE READING