Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.

  title={Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.},
  author={Christian Sell and Renato Baserga and Raphael Rubin},
  journal={Cancer research},
  volume={55 2},
The interaction of insulin-like growth factors (IGF) with the IGF-I receptor promotes cell proliferation and survival. We examined the role of the IGF-I receptor as a possible direct inhibitor of apoptosis induced by the topoisomerase I inhibitor etoposide. When exposed to this agent, BALB/c 3T3 cells that constitutively overexpress the human IGF-I receptor (p6 cells) arrested in S phase and subsequently underwent apoptosis as determined by the appearance of a pre-G1 apoptotic peak when studied… CONTINUE READING

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