Insulin-like growth factor I: the yin and yang of muscle atrophy.

@article{Heszele2004InsulinlikeGF,
  title={Insulin-like growth factor I: the yin and yang of muscle atrophy.},
  author={Maria F Chacon Heszele and Stephen R. Price},
  journal={Endocrinology},
  year={2004},
  volume={145 11},
  pages={4803-5}
}
Skeletal muscle is the largest pool of protein in the body. Maintenance of its mass involves a delicate balance between protein synthesis and degradation. The dynamic nature of muscle is evident when one considers that healthy adults turn over 3.5–4.5 g of protein/kg d—stated another way, an average individual synthesizes and degrades approximately 1.0–1.5 kg protein per day (1). Therefore, a small, sustained change in either synthesis or degradation can have a significant impact on muscle mass… CONTINUE READING
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Role of the insulin-like growth factor I decline in the induction of atrogin-1/MAFbx during fasting and diabetes

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