Insulin-like growth factor I: the yin and yang of muscle atrophy.

  title={Insulin-like growth factor I: the yin and yang of muscle atrophy.},
  author={Maria F Chacon Heszele and Stephen R. Price},
  volume={145 11},
Skeletal muscle is the largest pool of protein in the body. Maintenance of its mass involves a delicate balance between protein synthesis and degradation. The dynamic nature of muscle is evident when one considers that healthy adults turn over 3.5–4.5 g of protein/kg d—stated another way, an average individual synthesizes and degrades approximately 1.0–1.5 kg protein per day (1). Therefore, a small, sustained change in either synthesis or degradation can have a significant impact on muscle mass… CONTINUE READING
18 Citations
30 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 30 references

, metabolism and life span

  • J Downward
  • 2004

Role of the insulin-like growth factor I decline in the induction of atrogin-1/MAFbx during fasting and diabetes

  • M Dehoux, R Van Beneden, +5 authors J-P Thissen
  • Endocrinology
  • 2004
2 Excerpts

Similar Papers

Loading similar papers…