Insulin-like growth factor 1 regulates developing brain glucose metabolism.

  title={Insulin-like growth factor 1 regulates developing brain glucose metabolism.},
  author={Clara M Cheng and Rick R Reinhardt and Won Hyuck Lee and Gilles Joncas and Sejal C. Patel and Carolyn A. Bondy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 18},
The brain has enormous anabolic needs during early postnatal development. This study presents multiple lines of evidence showing that endogenous brain insulin-like growth factor 1 (Igf1) serves an essential, insulin-like role in promoting neuronal glucose utilization and growth during this period. Brain 2-deoxy-d- [1-(14)C]glucose uptake parallels Igf1 expression in wild-type mice and is profoundly reduced in Igf1-/- mice, particularly in those structures where Igf1 is normally most highly… CONTINUE READING


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