Insulin-like growth factor 1 regulates developing brain glucose metabolism.

@article{Cheng2000InsulinlikeGF,
  title={Insulin-like growth factor 1 regulates developing brain glucose metabolism.},
  author={Clara M Cheng and Rick R Reinhardt and Won Hyuck Lee and Gilles Joncas and Sejal C. Patel and Carolyn A. Bondy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 18},
  pages={10236-41}
}
The brain has enormous anabolic needs during early postnatal development. This study presents multiple lines of evidence showing that endogenous brain insulin-like growth factor 1 (Igf1) serves an essential, insulin-like role in promoting neuronal glucose utilization and growth during this period. Brain 2-deoxy-d- [1-(14)C]glucose uptake parallels Igf1 expression in wild-type mice and is profoundly reduced in Igf1-/- mice, particularly in those structures where Igf1 is normally most highly… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 53 extracted citations

Similar Papers

Loading similar papers…