Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma.

@article{Friedrichs2008InsulinlikeGF,
  title={Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma.},
  author={Nicolaus Friedrichs and Judit Kuechler and Elmar Endl and Arend Koch and Jacqueline Czerwitzki and Peter Wurst and Daniel Metzger and Johannes Hubertus Schulte and Martin Ingo Holst and Lukas Heukamp and O Larsson and Shinji Tanaka and Akira Kawai and Eva 6 Wardelmann and Reinhard Buettner and Torsten Pietsch and Wolfgang Hartmann},
  journal={The Journal of pathology},
  year={2008},
  volume={216 4},
  pages={428-39}
}
Synovial sarcomas account for 5-10% of all soft tissue sarcomas and the majority of synovial sarcomas display characteristic t(X;18) translocations that result in enhanced transcription of the insulin-like growth factor-2 (IGF-2) gene. IGF-2 is an essential fetal mitogen involved in the pathogenesis of different tumours, leading to cellular proliferation and inhibition of apoptosis. Here we asked whether activation of IGF signalling is of functional importance in synovial sarcomas. We screened… CONTINUE READING