Insulin-like growth factor-1 receptor activation prevents hydrogen peroxide-induced oxidative stress, mitochondrial dysfunction and apoptosis

Abstract

Vascular disease is the leading cause of morbidity and mortality. Oxidative stress can cause endothelial cell apoptosis. Low insulin like growth factor-1 (IGF-1) has been linked to adverse risk profile and increased vascular disease incidence. Since IGF-1 acts as an important survival factor for multiple cell types, we undertook this study to investigate… (More)
DOI: 10.1007/s10495-011-0634-9

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@article{Hao2011InsulinlikeGF, title={Insulin-like growth factor-1 receptor activation prevents hydrogen peroxide-induced oxidative stress, mitochondrial dysfunction and apoptosis}, author={Chang-ning Hao and Yong-jian Geng and Fan Li and Tong Yang and Ding-feng Su and Jun-li Duan and Yangxin Li}, journal={Apoptosis}, year={2011}, volume={16}, pages={1118-1127} }