Insulin-like growth factor-1 modulation of intestinal epithelial cell restitution.

  title={Insulin-like growth factor-1 modulation of intestinal epithelial cell restitution.},
  author={Kuanghueih Chen and Riichiroh Nezu and Masafumi Wasa and Kinya Sando and Shinkichi Kamata and Yasuhiro Takagi and Akira Okada},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  volume={23 5 Suppl},
After superficial intestinal injury, the mucosal integrity is reestablished by rapid migration of epithelial cells from the adjacent area in a process called restitution. Our previous study suggested that growth hormone improves intestinal healing in an experimental small bowel ulceration, mediated by insulin-like growth factor-1 (IGF-1). The aim of the present study was to assess the role of IGF-1 in mucosal epithelial restitution using an in vitro epithelial wound model. Wounds were… CONTINUE READING

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