Insulin-like growth factor-1 enhances the efficacy of myoblast transplantation with its multiple functions in the chronic myocardial infarction rat model.

@article{Kanemitsu2006InsulinlikeGF,
  title={Insulin-like growth factor-1 enhances the efficacy of myoblast transplantation with its multiple functions in the chronic myocardial infarction rat model.},
  author={Naoki Kanemitsu and Keiichi Tambara and Goditha Upul Premaratne and Yu Kimura and Shinji Tomita and Teruhisa Kawamura and Koji Hasegawa and Yasuhiko Tabata and Masashi Komeda},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2006},
  volume={25 10},
  pages={1253-62}
}
BACKGROUND Myoblast transplantation (Tx) is promising for the improvement of cardiac function in ischemic cardiomyopathy. Insulin-like growth factor-1 (IGF-1) has anti-apoptotic and angiogenic effects, and induces myocyte hypertrophy. Our hypothesis is that topical and slow-release IGF-1 enhances the efficacy of Tx through its multiple functions. METHODS Four weeks after coronary artery ligation, Lewis rats were divided into four groups: (1) IGF-1+Tx, injection of 6 x 10(6) myoblasts into the… CONTINUE READING
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