Insulin-like growth factor-1 and progression of motor symptoms in early, drug-naïve Parkinson’s disease

  title={Insulin-like growth factor-1 and progression of motor symptoms in early, drug-na{\"i}ve Parkinson’s disease},
  author={Marina Picillo and Roberto Erro and Gabriella Santangelo and Rosario Pivonello and Katia Longo and Claudia Pivonello and Carmine Vitale and Marianna Amboni and Marcello Moccia and Annamaria Colao and Paolo Barone and M. T. Pellecchia},
  journal={Journal of Neurology},
Much pre-clinical evidence show that insulin-like growth factor 1 (IGF-1) provides protection against loss of dopaminergic neurons. Recently, IGF-1 has been proposed as a possible biomarker for early diagnosis of Parkinson’s disease (PD). We aimed to assess the relationship between serum IGF-1 levels and progression of motor symptoms in a cohort of drug-naïve PD patients. Serum IGF-1 was measured at baseline in 37 early, drug-naive PD patients; subsequently, patients were evaluated “on drug” by… CONTINUE READING
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