Insulin-like growth factor 1 (IGF-I) improves hepatic differentiation of human bone marrow-derived mesenchymal stem cells.

@article{Ayatollahi2011InsulinlikeGF,
  title={Insulin-like growth factor 1 (IGF-I) improves hepatic differentiation of human bone marrow-derived mesenchymal stem cells.},
  author={Maryam Ayatollahi and Masoud Soleimani and Bita Geramizadeh and Mohammad Hadi Imanieh},
  journal={Cell biology international},
  year={2011},
  volume={35 11},
  pages={1169-76}
}
The ability of MSCs (mesenchymal stem cells) to differentiate between other cell types makes these cells an attractive therapeutic tool for cell transplantation. This project was designed to improve transdifferentiation of human MSCs into liver cells using IGF-I (insulin-like growth factor 1) which, despite its important role in liver development, has not been used for in vitro hepatic differentiation. In the present study, the MSCs derived from healthy human bone marrow samples were cultured… CONTINUE READING
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