Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis
@article{Renehan2004InsulinlikeGF, title={Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis}, author={Andrew G. Renehan and Marcel Zwahlen and Christoph E. Minder and Sarah T O'dwyer and Stephen M. Shalet and Matthias Egger}, journal={The Lancet}, year={2004}, volume={363}, pages={1346-1353} }
1,579 Citations
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on.
- Biology, MedicineEndocrine-related cancer
- 2006
A cumulative meta-analysis demonstrates that earlier reported positive associations between IGFBP-3 and pre-menopausal breast cancer risk now seem less clear as large-size cohorts are published, and the reasons are complex and include differences in study design, lack of standardisation between assays, and variations in IGF BP-3 proteolytic activity.
Serum Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3 Concentrations and Prostate Cancer Risk: Results from the European Prospective Investigation into Cancer and Nutrition
- Medicine, BiologyCancer Epidemiology Biomarkers & Prevention
- 2007
In this large nested case-control study, serum IGF-I concentration is not strongly associated with prostate cancer risk, although the results are compatible with a small increase in risk, particularly for advanced-stage disease.
Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies
- Biology, MedicineEuropean Journal of Human Genetics
- 2009
Circulating levels of IGF1, IGF BP3 and IGFBP3 A−202C play a crucial role in carcinogenesis and could serve as susceptibility biomarkers for cancer development.
Insulin-like Growth Factor-1, IGF-binding Protein-3, C-peptide and Colorectal Cancer: a Case-control Study.
- Biology, MedicineAsian Pacific journal of cancer prevention : APJCP
- 2015
Evidence is provided for an association of insulin-related biomarkers with colorectal cancer risk and they point to consideration as candidate predictor markers.
Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3: A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study)
- Medicine, Biology
- 2010
Investigation of the influence of serum IGF-I and IGFBP-3 on prostate cancer risk in a casecontrol study nested within a large-scale cohort in Japan found that serum levels were not thought to be associated with risk of prostate cancer.
Serum Concentrations of Insulin-Like Growth Factor and Insulin-Like Growth Factor Binding Protein 3 and Recurrent Colorectal Adenomas
- Medicine, BiologyCancer Epidemiology Biomarkers & Prevention
- 2008
Results showed an unexpected null association, or even the suggestion of a reduction in risk for recurrent adenoma, with not just high IGFBP-3 concentration but also with high levels of IGF-I.
Circulating Insulin-like Growth Factor (IGF)-I and IGF Binding Protein (IGFBP)-3 Levels and Postmenopausal Breast Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort
- Medicine, BiologyHormones & cancer
- 2010
IGF-I and the IGF-I/IGFBP-3 molar ratio were positively, although not statistically significantly, associated with postmenopausal breast cancer risk.
The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer.
- Biology, MedicineLung cancer
- 2006
Longitudinal Study of Insulin-like Growth Factor, Insulin-like Growth Factor Binding Protein-3, and their Polymorphisms: Risk of Neoplastic Progression in Barrett's Esophagus
- Medicine, BiologyCancer Epidemiology Biomarkers & Prevention
- 2007
A potential role of the complex IGF system in neoplastic progression among persons with Barrett's esophagus is indicated, based on a relatively small number of outcomes and subject to several limitations.
Circulating Insulin-Like Growth Factor-I and Binding Protein-3 and the Risk of Breast Cancer
- Medicine, BiologyCancer Epidemiology Biomarkers & Prevention
- 2007
IG-I and IGFBP-3 were positively associated with breast cancer risk in older women but not in younger women, and more prospective studies are needed to clarify the age dependence of the association.
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Circulating levels of IGF-I and IGFBP-3 may predict the risk of developing advanced-stage prostate cancer, but their utility for screening patients with incident prostate cancer may be limited.
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Insulin-like growth factor I (IGF-I), IGF-binding proteins, and breast cancer.
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In premenopausal women, elevated serum IGF-I and IGFBP-3 are associated with increased breast cancer risk, whereas elevated serum IGBP-2 is inversely associated with risk of postmenopausal breast cancer.
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Response: More About: Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF- Binding Protein-3
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Ass associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer are suggested to be consistent during the first and the second 7-year follow-up intervals and among younger and older men.