Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism*

@article{Rajah1997InsulinlikeGF,
  title={Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-$\beta$1 on Programmed Cell Death through a p53- and IGF-independent Mechanism*},
  author={Roopmathy Rajah and Barbara Valentinis and Pinchas Cohen},
  journal={The Journal of Biological Chemistry},
  year={1997},
  volume={272},
  pages={12181 - 12188}
}
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is known to block IGF action and inhibit cell growth. IGFBP-3 is thought to act by sequestering free IGFs or, possibly, act via a novel IGF-independent mechanism. Supporting its role as a primary growth inhibitor, IGFBP-3 production has been shown to be increased by cell growth-inhibitory agents, such as transforming growth factor-β (TGF-β), and the tumor suppressor gene p53. In this paper, we demonstrate, for the first time, a novel… 

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