Insulin-like 3 signalling in testicular descent.

  title={Insulin-like 3 signalling in testicular descent.},
  author={Ibrahim M. Adham and Alexander I. Agoulnik},
  journal={International journal of andrology},
  volume={27 5},
Undescended testis is one of the most common congenital defects in the newborn boys and the common cause of cryptorchidism. If left untreated, this condition is strongly associated with infertility and drastically increased risk of testicular cancer in adulthood. Testis position in developing males is defined by sexual dimorphic differentiation of two gonadal ligaments, gubernaculum and cranial suspensory ligament. Recent transgenic mouse studies identified testicular hormone insulin-like 3… CONTINUE READING
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