Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.

@article{Tomboc2000Insulinlike3F,
  title={Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.},
  author={Marlah Tomboc and Peter Allen Lee and Mohamed Farouk M Mitwally and Francis X. Schneck and Mark F. Bellinger and Selma Feldman Witchel},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 11},
  pages={4013-8}
}
Cryptorchidism is a common anomaly of male sexual differentiation. Two phases of testicular descent are recognized, transabdominal and inguinoscrotal. With evidence that androgens and Müllerian inhibitory hormone were not completely responsible for testicular descent, the existence of a third testicular hormone mediating testicular descent was postulated. Insulin-like 3 (INSL3) [also known as relaxin-like factor (RLF) and Leydig insulin-like protein (LEY I-L)] is a member of the insulin/relaxin… CONTINUE READING

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