Insulin levels control female germline stem cell maintenance via the niche in Drosophila.

@article{Hsu2009InsulinLC,
  title={Insulin levels control female germline stem cell maintenance via the niche in Drosophila.},
  author={Hwei-Jan Hsu and Daniela Drummond-Barbosa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 4},
  pages={1117-21}
}
Stem cell maintenance depends on local signals provided by specialized microenvironments, or niches, in which they reside. The potential role of systemic factors in stem cell maintenance, however, has remained largely unexplored. Here, we show that insulin signaling integrates the effects of diet and age on germline stem cell (GSC) maintenance through the dual regulation of cap cell number (via Notch signaling) and cap cell-GSC interaction (via E-cadherin) and that the normal process of GSC and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 81 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Similar Papers

Loading similar papers…