Insulin levels, physical activity, and urinary catecholamine excretion of obese and non-obese rhesus monkeys.

@article{WoldenHanson1993InsulinLP,
  title={Insulin levels, physical activity, and urinary catecholamine excretion of obese and non-obese rhesus monkeys.},
  author={Tami Wolden‐Hanson and G Davis and Scott T. Baum and Joseph W. Kemnitz},
  journal={Obesity research},
  year={1993},
  volume={1 1},
  pages={
          5-17
        }
}
The hypothesis that spontaneous obesity in rhesus monkeys is associated with abnormalities in energy expenditure was tested. Obese (n=7) and non-obese (n=5) monkeys were described in terms of body size and composition, food intake, and physical activity. Additionally, the relationships among fasting and stimulated insulin levels in serum, C-peptide levels in serum and urine, and urinary catecholamines were examined. Obese animals had primarily abdominal deposition of excess body fat, as… Expand
Pioglitazone Increases Insulin Sensitivity, Reduces Blood Glucose, Insulin, and Lipid Levels, and Lowers Blood Pressure, in Obese, Insulin-Resistant Rhesus Monkeys
TLDR
Pioglitazone hydrochloride significantly improved fasting and postprandial levels of IRI, plasma glucose, and TG in a dose-related manner and was more marked for those animals with fasting hyperglycemia. Expand
Activity Measures in Rhesus Monkeys on Long-Term Calorie Restriction
TLDR
The increases in motor activity observed in one group of monkeys were consistent with results obtained from rodent studies of CR and aging, and increases in activity due to CR in a model other than the rodent are reported here, for the first time. Expand
Calorie restriction in rhesus monkeys
TLDR
Preliminary evidence suggests that CR will have beneficial effects on morbidity and mortality and a battery of measures are prepared to provide a thorough and relevant analysis of the effectiveness of CR at delaying the onset of age-related disease and maintaining function later into life. Expand
Non-invasive assessment of metabolic responses to food restriction using urinary triiodothyronine and cortisol measurement in macaques.
TLDR
Since uTT3 is reasonably robust to many issues associated with collection and storage of urine samples under field conditions, it is a promising biomarker for studies of energetic condition and basal metabolic rate in wild macaques. Expand
Urinary C-Peptide Measurement as a Marker of Nutritional Status in Macaques
TLDR
It is concluded that UCPs may be used as reliable biomarkers of body condition and nutritional status in studies of free-ranging catarrhines and possibly also in non-primate mammals. Expand
Effect of acute and chronic caloric restriction and metabolic glucoprivation on spontaneous physical activity in obesity-prone and obesity-resistant rats.
  • J. Teske, C. Kotz
  • Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2009
TLDR
The fact that chronic CR failed to result in significant changes in SPA in OR rats suggests that these rats may be especially unresponsive to treatments modulating feeding, which may in part mediate phenotypic traits of lean rats. Expand
Reduction of renal dopamine receptor expression in obese Zucker rats: role of sex and angiotensin II.
TLDR
Increased angiotensin II type 1 receptor activity may be mechanistically involved in the decreased expression of D1R and D2R in obese rats, which could induce salt sensitivity and elevate blood pressure. Expand
Causes of Obesity and Consequences of Obesity Prevention in Non-human Primates and Other Animal Models
TLDR
The present review will focus principally upon the spontaneously occurring form of obesity in non-human primates and in rodents, the form(s) of obesity that are highly likely to be directly relevant to most human obesity. Expand
Caloric restriction mimetics: physical activity and body composition changes.
TLDR
Whether changes in exercise behavior and body composition produce similar changes as those found in dietary restriction and whether these changes can be used to either replace or enhance the beneficial effects of dietary restriction is investigated. Expand
Potential applications of urinary C-peptide of insulin for comparative energetics research.
TLDR
Preliminary results indicate that further development of the urinary C-peptide method could expand opportunities to quantify energetic condition for great apes in the wild and generate new data for comparative research. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 38 REFERENCES
Obesity in male and female rhesus monkeys: fat distribution, glucoregulation, and serum androgen levels.
TLDR
It is concluded that obese male and female rhesus monkeys have patterns of fat distribution and glucoregulatory abnormalities similar to those of humans with upper body obesity. Expand
Characteristics of spontaneous obesity in male rhesus monkeys
TLDR
It is concluded that some adult male rhesus monkeys develop obesity without obvious differences in eating behavior and that obese monkeys, like obese humans, are at risk for diabetes mellitus and its complications. Expand
Urinary catecholamines, plasma insulin and environmental factors in relation to body fat distribution.
TLDR
In men taking no adrenergic antagonists, intra-abdominal fat showed a unique set of relationships to metabolic parameters which could be further related to certain environmental variables, and was found to be related to use of beta-adrenergic antagonists. Expand
Glucose-induced norepinephrine levels and obesity resistance.
TLDR
The results suggest that rats predisposed to become DR on the CM diet have dampened sympathetic activation after a glucose load, possibly because of heightened end-organ responsiveness to NE. Expand
Adiposity, anthropometric measures, and plasma insulin levels of rhesus monkeys.
TLDR
The similarities to studies in humans indicate the importance of the spontaneously obese adult rhesus monkey as an animal model in the study of obesity. Expand
Short-term changes in energy intake and serum insulin, neutral amino acids, and urinary catecholamine excretion in women.
TLDR
Urinary free norepinephrine and total dopamine levels were also increased during overeating, suggesting both sympathetic and dopaminergic activation during ove treating after undereating. Expand
Obesity in free-ranging rhesus macaques.
  • S. Schwartz, J. Kemnitz, C. Howard
  • Medicine
  • International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • 1993
Spontaneous obesity in free-ranging rhesus macaques (Macaca mulatta) was assessed in terms of body size, body fat distribution, endocrinological/metabolic indices, and social and familial factors.Expand
Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man
TLDR
Insulin infusion increases sympathetic nervous system activity in the absence of changes in blood glucose in nonobese young men using glucose clamp techniques. Expand
Changes in lipoprotein concentrations during the development of noninsulin-dependent diabetes mellitus in obese rhesus monkeys (Macaca mulatta).
TLDR
The middle-aged obese rhesus monkey is an animal model in which these defects can be separated in time during the development of diabetes, and can be used to study lipoprotein abnormalities as they occur both before and in noninsulin-dependent diabetes. Expand
Energy expenditure in obesity.
  • E. Jéquier
  • Medicine
  • Clinics in endocrinology and metabolism
  • 1984
TLDR
It is concluded that a thermogenic defect can contribute to the development of obesity in some predisposed subjects and insulin resistance and/or a blunted response of the sympathetic nervous system have been reported. Expand
...
1
2
3
4
...