Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes.

@article{Hamel2001InsulinIP,
  title={Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes.},
  author={Frederick G. Hamel and Robert G. Bennett and Jennifer L Upward and William C. Duckworth},
  journal={Endocrinology},
  year={2001},
  volume={142 6},
  pages={2702-6}
}
Inhibition by insulin of long chain fatty acid oxidation in mitochondria is mediated in part by elevating malonyl-CoA levels, which inhibit carnitine palmitoyl-transferase I. Whether insulin alters peroxisomal oxidation has not been studied. We present data which show that insulin inhibits the oxidation of palmitic acid by peroxisomes (IC(50) = 8.5 x 10(-11) M) at hormone concentrations 100-fold less than those needed for mitochondrial inhibition (IC(50) = 1.3 x 10(-8) M). We used a purified… CONTINUE READING

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