Insulin inhibits inflammation and promotes atherosclerotic plaque stability via PI3K-Akt pathway activation.

Abstract

Toll-like receptor (TLR) 4 induced inflammation was reported to play an important role in atherosclerotic plaque stability. Recent studies indicated that insulin could inhibit inflammation by activating phosphatidylinositol 3-kinase-Akt-dependent (PI3K-Akt) signaling pathway. In the current study, we hypothesized that insulin would inhibit TLR4 induced… (More)
DOI: 10.1016/j.imlet.2015.12.003

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