Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity.

@article{Moghetti1996InsulinIA,
  title={Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity.},
  author={Paolo Moghetti and Roberto Castello and Carlo Negri and Flavia Tosi and Giorgio Spiazzi and Elisabetta Brun and Rina Balducci and Vincenzo Toscano and Michele Muggeo},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 3},
  pages={881-6}
}
Recent data suggest that insulin is a modulator of ovarian and adrenal steroidogenesis and that, in the ovary of hyperandrogenic women, hyperinsulinemia might cause dysregulation of cytochrome P450c17 alpha activity. To further assess in vivo the effects of insulin on adrenal steroidogenesis, ACTH stimulation was carried out in 21 hyperandrogenic women during a 3-h hyperinsulinemic (80 mU/m2-min) euglycemic clamp. In all of these women the procedure was repeated during saline infusion as n… CONTINUE READING

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