Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons.

@article{Sathianathan2003InsulinIC,
  title={Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons.},
  author={Vivian J Sathianathan and Ant{\'o}nio Avelino and Ana Charrua and P{\'e}ter S{\'a}ntha and Kl{\'a}ra Matesz and Francisco J. G{\'o}mez-de la Cruz and Istv{\'a}n Nagy},
  journal={The European journal of neuroscience},
  year={2003},
  volume={18 9},
  pages={2477-86}
}
Previous findings show that both the vanilloid receptor 1 and the insulin receptor are expressed on small primary sensory neurons. As insulin evokes activity in second messengers which could induce opening of the vanilloid receptor 1, we examined, by using the cobalt-uptake technique, whether or not insulin can activate cultured rat primary sensory neurons through activating the vanilloid receptor 1. Capsaicin (50, 100 and 500 nm) induced concentration-dependent labelling in primary sensory… CONTINUE READING

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