Insulin-induced translocation of protein kinase B to the plasma membrane in rat adipocytes.

@article{Gransson1998InsulininducedTO,
  title={Insulin-induced translocation of protein kinase B to the plasma membrane in rat adipocytes.},
  author={Olga G{\"o}ransson and J. Wijkander and Vincent C. Manganiello and Eva Degerman},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={246 1},
  pages={249-54}
}
Protein kinase B (PKB) has previously been shown to be activated in response to insulin and growth factor stimulation. The activation mechanism has been suggested to involve translocation of PKB to membranes, where it is phosphorylated and activated. Insulin-induced translocation of PKB has not been demonstrated in a physiological target cell. Therefore we have used the primary rat adipocyte to investigate insulin-induced translocation of PKB. In the presence of 1 nM insulin translocation of… CONTINUE READING