Insulin-induced sympathetic activation and vasodilation in skeletal muscle. Effects of insulin resistance in lean subjects.

@article{Vollenweider1995InsulininducedSA,
  title={Insulin-induced sympathetic activation and vasodilation in skeletal muscle. Effects of insulin resistance in lean subjects.},
  author={L J Vollenweider and Luc Tappy and Reza Owlya and Eric J{\'e}quier and Pascal Nicod and Urs Scherrer},
  journal={Diabetes},
  year={1995},
  volume={44 6},
  pages={641-5}
}
Insulin-induced stimulation of blood flow and sympathetic nerve activity in skeletal muscle tissue is impaired in obesity, but the underlying mechanism is unknown. To determine whether insulin resistance alters sympathetic and vasodilatory responses to euglycemic hyperinsulinemia, in eight healthy subjects we measured calf blood flow and muscle sympathetic nerve activity (MSNA) (n = 5) during insulin/glucose infusion (euglycemic hyperinsulinemic [6 pmol.kg-1.min-1] clamp) performed alone and… CONTINUE READING

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