Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway

  title={Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway},
  author={Brian T Fife and Indira Guleria and Melanie Gubbels Bupp and Todd N. Eagar and Qizhi Tang and H{\'e}l{\`e}ne Bour-Jordan and H. Yagita and Miyuki Azuma and Mohamed H. Sayegh and Jeffrey A Bluestone},
  journal={The Journal of Experimental Medicine},
  pages={2737 - 2747}
The past decade has seen a significant increase in the number of potentially tolerogenic therapies for treatment of new-onset diabetes. However, most treatments are antigen nonspecific, and the mechanism for the maintenance of long-term tolerance remains unclear. In this study, we developed an antigen-specific therapy, insulin-coupled antigen-presenting cells, to treat diabetes in nonobese diabetic mice after disease onset. Using this approach, we demonstrate disease remission, inhibition of… CONTINUE READING


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Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.

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