Insulin-induced relaxation of rat mesenteric artery is mediated by Ca(2+)-activated K(+) channels.

@article{Iida2001InsulininducedRO,
  title={Insulin-induced relaxation of rat mesenteric artery is mediated by Ca(2+)-activated K(+) channels.},
  author={Shizuka Iida and Hisao Taguchi and Nobuhide Watanabe and Toshio Kushiro and Katsuo Kanmatsuse},
  journal={European journal of pharmacology},
  year={2001},
  volume={411 1-2},
  pages={
          155-160
        }
}
We tested the hypothesis that relaxation of the rat mesenteric artery in response to insulin is mediated by K(+) channels. Two concentrations of insulin (10 and 100 mU/ml) induced relaxation of the artery by 6+/-1%, 24+/-3% (mean+/-S.E.M.). Denudation of the endothelium or precontraction by KCl (30 mM), clotrimazole (10 microM), a cytochrome P450 inhibitor, charybdotoxin (30 nM) an inhibitor of large-conductance Ca(2+)-activated K(+) channels, abolished the relaxation of the artery in response… CONTINUE READING