Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.

@article{Kitamura1999InsulininducedPA,
  title={Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.},
  author={Takatoshi Kitamura and Yukihiko Kitamura and Shun'ichi Kuroda and Yasuhisa Hino and Munetoshi Ando and Kazuhiko Kotani and Hiroaki Konishi and Hiromitsu Matsuzaki and Ushio Kikkawa and Wataru Ogawa and Masato Kasuga},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 9},
  pages={
          6286-96
        }
}
Cyclic nucleotide phosphodiesterase (PDE) is an important regulator of the cellular concentrations of the second messengers cyclic AMP (cAMP) and cGMP. Insulin activates the 3B isoform of PDE in adipocytes in a phosphoinositide 3-kinase-dependent manner; however, downstream effectors that mediate signaling to PDE3B remain unknown. Insulin-induced phosphorylation and activation of endogenous or recombinant PDE3B in 3T3-L1 adipocytes have now been shown to be inhibited by a dominant-negative… CONTINUE READING
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