Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB.

@article{Ahmad2007InsulininducedFO,
  title={Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB.},
  author={Faiyaz Ahmad and Rebecka Lindh and Yan Tang and Marie C Weston and Eva Degerman and Vincent C. Manganiello},
  journal={The Biochemical journal},
  year={2007},
  volume={404 2},
  pages={257-68}
}
Fractionation of 3T3-L1 adipocyte membranes revealed that PDE3B (phosphodiesterase 3B) was associated with PM (plasma membrane) and ER (endoplasmic reticulum)/Golgi fractions, that insulin-induced phosphorylation/activation of PDE3B was greater in internal membranes than PM fractions, and that there was no significant translocation of PDE3B between membrane fractions. Insulin also induced formation of large macromolecular complexes, separated during gel filtration (Superose 6 columns) of… CONTINUE READING

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