Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

@article{Vatner2015InsulinindependentRO,
  title={Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.},
  author={Daniel F Vatner and Sachin K. Majumdar and Naoki Kumashiro and Max C. Petersen and Yasmeen Rahimi and Arijeet K. Gattu and Mitchell Bears and Jo{\~a}o-Paulo G. Camporez and Gary W. Cline and Michael J Jurczak and Varman T Samuel and Gerald I Shulman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 4},
  pages={1143-8}
}
A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance--wherein insulin fails to suppress hepatic glucose production yet continues to stimulate lipogenesis, resulting in hyperglycemia, hyperlipidemia, and hepatic steatosis. Although efforts to explain this have focused on finding a branch point in insulin signaling where hepatic glucose and lipid metabolism diverge, we hypothesized that hepatic triglyceride synthesis could be driven by substrate… CONTINUE READING
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Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research • 2012
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