Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

  title={Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.},
  author={Daniel F Vatner and Sachin K. Majumdar and Naoki Kumashiro and Max C. Petersen and Yasmeen Rahimi and Arijeet K. Gattu and Mitchell Bears and Jo{\~a}o-Paulo G. Camporez and Gary W. Cline and Michael J Jurczak and Varman T Samuel and Gerald I Shulman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 4},
A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance--wherein insulin fails to suppress hepatic glucose production yet continues to stimulate lipogenesis, resulting in hyperglycemia, hyperlipidemia, and hepatic steatosis. Although efforts to explain this have focused on finding a branch point in insulin signaling where hepatic glucose and lipid metabolism diverge, we hypothesized that hepatic triglyceride synthesis could be driven by substrate… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 20 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 42 extracted citations


Publications referenced by this paper.
Showing 1-10 of 39 references

Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…